Next Generation Fellow
Centre for Trophoblast Research & Department of Obstetrics and Gynaecology
Current Research Interests
1. Understanding the role of fetal sex-differences in placental function in normal and complicated pregnancies.
2. Placental metabolism in preeclampsia and fetal growth restriction.
3. Placental-specific gene editing system to study the mechanisms underlying pregnancy disorders.
My current research focuses on the role of placental metabolism in mediating sex-specific responses during pre-eclampsia and fetal growth restriction. I am testing the hypothesis that genes which escape X-chromosome inactivation specifically in the placenta mediate sex-differences in placental function with consequences on adverse fetal outcomes. An additional area of my research is the use of lentiviral vectors to perform placental-specific gene manipulation (overexpression or deletion) in mice. A key feature of my research is the combination of a variety of models including primary human cells and rodent models, and the use of clinical human samples to answer questions of biological and clinical significance
- Next Generation Fellow (Oct 2018-current), Centre for Trophoblast Research and Department of Obstetrics & Gynaecology, University of Cambridge.
- Research Associate (2015-2018), Department of Obstetrics & Gynaecology, University of Cambridge.
- Instructor (2014-2015), Division of Reproductive Science, Department of Obstetrics & Gynecology, University of Colorado School of Medicine, Aurora, Colorado.
- Postdoctoral Fellow (2011-2014), Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas, Health Science Center, San Antonio, Texas.
- PhD in Placental Physiology (2011), School of Women’s & Infants’ Health, University of Western Australia.
- MSc in Pharmacology (2006), Liggins Institute and Department of Pharmacology, University of Auckland, New Zealand.
- BSc in Biomedical Science (2004), University of Auckland, New Zealand.
- Gong S*, Sovio U*, Aye ILMH*, Gaccioli F*, Dopierala J, Johnson MD, Wood AM, Cook E, Jenkins BJ, Koulman A, Casero Jr. RA, Constancia M, Charnock-Jones DS, Smith GCS. Placental polyamine metabolism differs by fetal sex, fetal growth restriction and preeclampsia. JCI Insight. 2018; 3(13): e120723. (*equal contribution)
- Aye ILMH, Moraitis AA, Stanislaus D, Charnock-Jones DS, Smith GCS. Retosiban prevents stretch-induced human myometrial contractility and delays labor in Cynomolgus monkeys. J Clin Endocrinol Metab. 2018; 103(3): 1056-1067.
- Aye IL†, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015; 112(41):12858-12863. (†corresponding author)
- Aye IL, Rosario FJ, Powell TL, Jansson T. Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016; 113(3):E261.
- Aye IL†, Jansson T, Powell TL. TNF-α stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling. Physiol Rep. 2015; 3(10):e12594. (†corresponding author)
- Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta 2015; 36(7):709-715.
- Gaccioli F*, Aye IL*, Roos S, Lager S, Ramirez VI, Kanai Y, Powell TL, Jansson T. Expression and functional characterization of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol 2015; 13(1):57 (*equal contribution)
- Lager S*, Aye IL*, Gaccioli F, Ramirez VI, Jansson T, Powell TL. Labor inhibits placental mechanistic target of rapamycin complex 1 signaling. Placenta. 2014; 35(12):1007-1012 (*equal contribution).
- Aye IL*†, Lager S*, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, Powell TL. Increasing maternal BMI is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014; 90(6):129. (*equal contribution, †corresponding author).
- Aye IL†, Gao X, Weintraub S, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis. Mol Endocrinol. 2014; 28 (4):512-524. (†corresponding author)
- Abumaree MH, Alahari S, Albrecht C, Aye IL, et al. IFPA Meeting 2013 Workshop Report I: diabetes in pregnancy, maternal dyslipidemia in pregnancy, oxygen in placental development, stem cells and pregnancy pathology. Placenta 2014; 35(S):4-9
- Aye IL†, Jansson T, Powell TL. Interleukin-1β inhibits insulin signaling and prevents insulin-stimulated System A amino acid transport in primary human trophoblasts. Mol Cell Endocrinol. 2013; 381 (1-2):46-55. (†corresponding author)
- Aye IL and Keelan JA. Placental ABC transporters, cellular toxicity and stress in pregnancy. Chem Biol Interact. 2013; 203 (2):456-466.
- Aye IL, Powell TL, Jansson T. Adiponectin – The missing link between maternal adiposity, placental transport and fetal growth? Placenta. 2013; 34 (Suppl A):S40-S45. (Selected for issue cover)
- Jansson T, Aye IL, Goberdhan DC. The emerging role of mTORC1 signalling in placental nutrient-sensing. Placenta 2012; 33(Suppl 2):e23-29.
- Singh AT, Dharmarajan A, Aye IL, Keelan JA. Ceramide biosynthesis and metabolism in trophoblast syncytialization. Mol Cell Endocrinol. 2012;362(1-2):48-59.
- Aye IL†, Waddell BJ, Mark PJ and Keelan JA. Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-kappaB. Mol Hum Reprod. 2012;18(7):341-53. (†corresponding author)
- Singh AT, Dharmarajan A, Aye IL, Keelan JA. Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization. Reprod Biomed Online. 2012;24(2):224-234.
- Keelan JA, Aye IL, Mark PJ, Waddell BJ. ABCA1 and placental cholesterol efflux. Placenta. 2011;32(9):708-709.
- Al-Khan A, Aye IL, et al. IFPA Meeting 2010 Workshops Report II: Placental pathology; trophoblast invasion; fetal sex; parasites and the placenta; decidua and embryonic or fetal loss; trophoblast differentiation and syncytialisation. Placenta. 2011; 32(Suppl2):S90-99.
- Aye IL, Waddell BJ, Mark PJ and Keelan JA. Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. Placenta. 2011;32(2):183-91.
- Aye IL, Waddell BJ, Mark PJ and Keelan JA. Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. Biochim Biophys Acta. 2010;1801(9):1013-24.
- Aye IL, Singh AT and Keelan JA. Transport of lipids by ABC proteins: interactions and implications for cellular toxicity, viability and function. Chem Biol Interact. 2009;180(3):327-39.
- Aye IL, Paxton JW, Evseenko DA and Keelan JA. Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes. Placenta. 2007;28(8-9):868-77.
Pubmed link to bibliography: https://tinyurl.com/y8bw9bsx
- Irving L.M.H. Aye, Susanne Lager, Theresa L. Powell, Chapter 6: The role of placental inflammasomes in linking the adverse effects of maternal obesity on fetal development. In: Metabolic Syndrome and Complications of Pregnancy. Enrico M. Ferrazzi & Barry Sears (Editors). Springer Press.
Centre for Trophoblast Research – Next Generation Fellowship
EMBO – Short Term Fellow
National Institutes of Health – K99 Pathway to Independence Award
CWHR University of Colorado School of Medicine – Research Development Award