
Irving Aye
Group Leader & MRC Career Development Fellow
Publications
- Aye ILMH, Gong S, Avellino G, Barbagallo R, Gaccioli F, Jenkins BJ, Koulman A, Murray AJ,
Charnock-Jones DS, Smith GCS. Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation.
Nature Commun Biol (2022) in press. - Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen T, Powell TL, Jansson T. Insulin-stimulated adiponectin secretion in pregnancy is mediated by inhibition of adiponectin ubiquitination and degradation and is impaired in obesity. J Clin Endocrinol Metab 2022; 107(1):53-66
- Gong S, Sovio U, Aye ILMH, Gaccioli F, Dopierala J, Johnson MD, Wood AM, Cook E, Jenkins BJ, Koulman A, Casero Jr. RA, Constancia M, Charnock-Jones DS, Smith GCS. Placental polyamine metabolism differs by fetal sex, fetal growth restriction and preeclampsia. JCI Insight. 2018; 3(13): e120723 (*equal contribution)
- Aye ILMH, Aiken CE, Charnock-Jones DS, Smith GC. Placental energy metabolism in health and disease – significance of development and implications for preeclampsia. Am J Obstet Gynecol 2022; 226(2S):S928-S944
- Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015; 112(41):12858-12863
Funding
Current:
Medical Research Council (MRC) – Career Development Award
Previous:
Centre for Trophoblast Research (CTR) – Next Generation Fellowship
European Molecular Biology Organisation (EMBO) – Short Term Fellowship
National Institutes of Health (NIH) USA – K99 Pathway to Independence University of Colorado School of Medicine – Research Development Award
Location
Room 104, University Department of Obstetrics & Gynaecology, Level 2, The Rosie Hospital
Phone: +44 (0)1223 (3)36874