Publications

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1. Gaccioli F, Sovio U, Gong S, Cook E, Charnock-Jones DS, Smith GCS. Increased placental sFLT1 (Soluble fms-Like Tyrosine Kinase Receptor-1) drives the antiangiogenic profile of maternal serum preceding preeclampsia but not fetal growth restriction. Hypertension 2023; 80 (2), 325-334.
2. Sovio U, Clayton GL, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. Metabolomic Identification of a Novel, Externally Validated Predictive Test for Gestational Diabetes Mellitus. J Clin Endocrinol Metab. 2022 Jul 14;107(8):e3479-e3486.
3. Aye ILMH, Gong S, Avellino G, Barbagallo R, Gaccioli F, Jenkins BJ, Koulman A, Murray AJ, Stephen Charnock-Jones D, Smith GCS.Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation. Commun Biol. 2022 Jun 15;5(1):586.
4. Sovio U, Goulding N, McBride N, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. A Maternal Serum Metabolite Ratio Predicts Large for Gestational Age Infants at Term: A Prospective Cohort Study. J Clin Endocrinol Metab. 2022 Mar 24;107(4):e1588-e1597.
5. Gong S, Gaccioli F, Dopierala J, Sovio U, Cook E, Volders P, Martens L, Kirk PDW, Richardson S, Smith GCS, Charnock-Jones DS. The RNA landscape of the human placenta in health and disease. Nature Communications 2021; 12 (1), 2639.
6. Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Smith GCS. Slowing of fetal growth and elevated maternal serum sFLT1:PlGF are associated with early term spontaneous labor. Am J Obstet Gynecol. 2021 Nov;225(5):520.e1-520.e10.
7. Gaccioli F*, Lager S*, de Goffau MC*, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS. Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother. Nature Microbiology 2020 Jul 1; 5(7): 901–908. *equal contribution
8. Sovio U, Goulding N, McBride N, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. A maternal serum metabolite ratio predicts term fetal growth restriction. Nature Medicine 2020;26(3):348-353.
9. de Goffau MC, Lager SM, Sovio U, Gaccioli F, Cook E, Peacock SJ, Parkhill J, Charnock-Jones DS, Smith GCS. Human placenta has no microbiome but can contain potential pathogens. Nature 2019;572:329-334.
10. Gaccioli F*, Sovio U*, Cook E, Hund M, Charnock-Jones DS, and Smith GCS. Screening for fetal growth restriction using ultrasound and the sFLT1:PlGF ratio in a prospective cohort study of nulliparous women. Lancet Child Adolesc Health 2018;2(8):569-581. *equal contribution
11. Gong S*, Sovio U*, Aye IL*, Gaccioli F*, Dopierala J, Johnson MD, Wood AM, Cook E, Jenkins BJ, Koulman A, Casero RA, Constância M, Charnock-Jones DS, and Smith GCS. Placental polyamine metabolism differs by fetal sex, fetal growth restriction and preeclampsia. JCI Insight 2018;3(13). *equal contribution
12. Sovio U*, Gaccioli F*, Cook E, Hund M, Charnock-Jones DS, and Smith GC. Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio: A Prospective Cohort Study of Unselected Nulliparous Women. Hypertension 2017;69(4):731-738. *equal contribution
13. Cleaton MA, Dent CL, Howard M, Corish JA, Gutteridge I, Sovio U, Gaccioli F, Takahashi N, Bauer SR, Charnock-Jones DS, et al. Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction. Nat Genet 2016;48(12):1473-1480