Research interests
- Placental architecture and perturbations
- Single cell transcriptomics
- Molecular biology method development
Publications
Highlighted:~
- Angelova, D.M. & Brown, D.R. (2019) Microglia and the Aging Brain: Are Senescent Microglia the Key to Neurodegeneration? J Neurochem
- Angelova, D.M. & Brown, D.R. (2018) Altered Processing of Beta-amyloid in SH-SY5Y cells induced by Model Senescent Microglia. ACS Chemical Neuroscience
- Angelova, D. & Brown, D. (2018) Model Senescent Microglia Induce Disease Related Changes in α- Synuclein Expression and Activity. Biomolecules
- Angelova, D.M., Jones, H.B.L. & Brown, D.R. (2018) Levels of α- and β-synuclein regulate cellular susceptibility to toxicity from α-synuclein oligomers. FASEB Journal
- Angelova, D. & Brown, D. (2015) Iron, Aging, and Neurodegeneration. Metals
Affiliations
- Centre for Trophoblast Research
- Cambridge Reproduction SRI
- Nanjing Tech University
- Sphere Fluidics
- Hemberger Lab, University of Calgary
Research summary
I am a postdoc at the Department of Obstetrics and Gynaecology where I started in 2019 after completing my PhD at the University of Bath. I am a member of the Charnock-Jones lab and my research focuses on applying single cell transcriptomics to the characterisation of the placenta as well at trophoblast cells in-vitro.
I’m currently developing a novel microfluidics-based single cell sequencing technology in collaboration with Nanjing Tech University and Sphere Fluidics.
This will be applied to characterise the heterogeneity and complex interplay between different placental cell types which can help uncover their role in both development and differentiation and pathology
Location
Room 106, University Department of Obstetrics & Gynaecology, Level 2, The Rosie Hospital
Phone: +44 (0)1223 (7)62321 (lab) or (3)36870