Are you currently less than four months pregnant with your first baby and attending antenatal appointments at the Rosie Hospital? If so, please read on.
We are conducting a research study where we perform extra scans at 28 and 36 weeks. We are looking for women, pregnant with their first baby, who are interested in taking part.
You can find out more about the study from the Participant Information Leaflet
Alternatively, you can obtain the leaflet by email email@example.com or write to us at the Department of Obstetrics and Gynaecology, Cambridge University, Box 223 The Rosie Hospital, Robinson Way, Cambridge, CB2 0SW, UK.
If after reading the leaflet you think you might be interested in taking part, please get in touch using the contact details on the last page. We can then arrange for you to see a member of our research team to chat it over and answer any questions, before giving your consent.
This study follows up the Pregnancy Outcome Prediction Study (POPS), a study of 4,512 women having first singleton pregnancies, recruited between 2008 and 2013. Women were serially scanned and had blood obtained at recruitment, 20, 28 and 36 weeks of gestational age. After delivery, samples were collected from the placenta, umbilical cord, and cord blood. The study generated a simple screening test which is strongly predictive for preeclampsia and FGR at term. The test combines maternal risk factors, ultrasound and measurement of placentally-derived proteins in maternal serum.
In POPS2 we want to collect similar data and samples from approximately ~4,500 unselected nulliparous women to address the following aims:
- to assess whether the test generated by POPS really works and to see whether we can improve pregnancy outcome in women who screen high risk by inducing labour early;
- to collect more blood samples in order to evaluate new blood tests that might enhance prediction of complicated pregnancies;
- to test a promising new method, looking to see whether chemical modifications to the DNA in placenta can be seen in maternal blood.
This study will help us to develop new predictors to detect a bigger proportion of pregnancy complications and to identify them earlier in pregnancy.
POPS2 is funded by the Wellcome Trust.
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