Publications from past and present departmental members.
2020
Townsend R, Sileo FG, Allotey J, Dodds J, Heazell A, Jorgensen L, Kim VB, Magee L, Mol B, Sandall J, Smith GCS, Thilaganathan B, von Dadelszen P, Thangaratinam S, Khalil A. Prediction of stillbirth: an umbrella review of evaluation of prognostic variables. BJOG 2020 Sep 15. doi: 10.1111/1471-0528.16510. Online ahead of print.
Snell KIE, Allotey J, Smuk M, Hooper R, Chan C, Ahmed A, Chappell LC, Von Dadelszen P, Green M, Kenny L, Khalil A, Khan KS, Mol BW, Myers J, Poston L, Thilaganathan B, Staff AC, Smith GCS, Ganzevoort W, Laivuori H, Odibo AO, Arenas Ramírez J, Kingdom J, Daskalakis G, Farrar D, Baschat AA, Seed PT, Prefumo F, da Silva Costa F, Groen H, Audibert F, Masse J, Skråstad RB, Salvesen KÅ, Haavaldsen C, Nagata C, Rumbold AR, Heinonen S, Askie LM, Smits LJM, Vinter CA, Magnus P, Eero K, Villa PM, Jenum AK, Andersen LB, Norman JE, Ohkuchi A, Eskild A, Bhattacharya S, McAuliffe FM, Galindo A, Herraiz I, Carbillon L, Klipstein- Grobusch K, Yeo SA, Browne JL, Moons KGM, Riley RD, Thangaratinam S. IPPIC Collaborative Network. External validation of prognostic models predicting pre- eclampsia: individual participant data meta-analysis. BMC Medicine 2020;18:302.
Ormesher L, Warrander L, Liu Y, Thomas S, Simcox L, Smith GCS, Myers JE, Johnstone ED. Risk stratification for early-onset fetal growth restriction in women with abnormal serum biomarkers: a retrospective cohort study. Scientific Reports 2020 Dec 17;10(1):22259. doi: 10.1038/s41598-020-78631-5.
Sexton JK, Coory M, Kumar S, Smith GCS, Gordon A, Chambers G, Pereira G, Raynes-Greenow C, Hilder L, Middleton P, Bowman A, Lieske SN, Warrilow K, Morris J, Ellwood D, Flenady V. Protocol for the development and validation of a risk prediction 1 model for stillbirths from 35 weeks gestation in Australia. Diagnostic and Prognostic Research 2020 In press.
Sovio U, Smith GCS. Comparison of estimated fetal weight percentiles near term for predicting extremes of birth weight percentile. American Journal of Obstetrics and Gynecology 2020 Aug 21:S0002-9378(20)30882-6. doi: 10.1016/j.ajog.2020.08.054. Online ahead of print.
Townsend R, Manji A, Allotey J, Heazell AEP, Jorgensen L, Magee LA, Mol BW, Snell KIE, Riley RD, Sandall J, Smith GCS, Patel M, Thilaganathan B, von Dadelszen P, Thangaratinam S, Khalil A. Can risk prediction models help us individualise stillbirth prevention? A systematic review and critical appraisal of published risk models. BJOG 2020 Sep 7. doi: 10.1111/1471-0528.16487. Online ahead of print.
Lager S, Sovio U, Eddershaw E, van der Linden MW, Yazar C, Cook E, Happerfield L, Jessop F, Sebire NJ, Charnock-Jones DS, Smith GCS. Abnormal placental CD8+ T cell infiltration is a feature of fetal growth restriction and pre-eclampsia. Journal of Physiology, 2020 Sep 4. doi: 10.1113/JP279532. Online ahead of print.
Aswad A, Aimola G, Wight D, Roychoudhury P, Zimmermann C, Hill J, Lassner D, Xie H, Huang ML, Parrish NF, Schultheiss HP, Venturini C, Lager S, Smith GCS, Charnock-Jones DS, Breuer J, Greninger AL, Kaufer BB. Evolutionary history of endogenous Human Herpesvirus 6 reflects human migration out of Africa. Molecular Biology and Evolution 2020 Jul 28:msaa190. doi: 10.1093/molbev/msaa190. Online ahead of print.
de Goffau MC, Charnock-Jones DS, Smith GCS, Parkhill J. Batch effects account for the main findings of an in utero human intestinal bacterial colonization study. Microbiome 2020 In press.
Moraitis AA, Shreeve N, Sovio U, Brocklehurst P, Heazell AEP, Thornton JG, Robson SC, Papageorghiou A, Smith GCS. Universal third trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome:, a systematic review and meta-analysis of diagnostic test accuracy. PLoS Medicine 2020 In press
Teulings NEWD, Wood AM, Sovio U, Ozanne SE, Smith GCS, Aiken CE. Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study. International Journal of Obesity 2020 Jun 15. doi: 10.1038/s41366-020-0627-2. Online ahead of print.
Smith GCS, Moraitis AA, Wastlund D, Thornton JG, Papageorghiou A, Sanders J, Heazell AEP, Robson SC, Sovio U, Brockelhurst P, Wilson ECF. A systematic review and cost-effectiveness analysis of the case for screening nulliparous women in late pregnancy using ultrasound. Health Technology Assessment 2020 In press.
Iliodromiti S, Smith GCS, Lawlor DA, Pell JP, Nelson SM. UK stillbirth trends in over 11 million births provide no evidence to support effectiveness of Growth Assessment Protocol program. Ultrasound in Obstetrics & Gynaecology 2020;55:599-604.
Gaccioli F, Lager S, de Goffau MC, Sovio U, Dopierala J, Gong S, Cook E, Sharkey A, Moffett A, Lee WK, Delles C, Venturini C, Breuer J, Parkhill J, Peacock SJ, Charnock-Jones DS, Smith GCS. Fetal inheritance of chromosomally integrated HHV-6 predisposes to preeclampsia in the mother. Nature Microbiology 2020;5:901-908
Furse S, Fernandez-Twinn D, Jenkins B, Meek CL, Williams HE, Smith GCS, Charnock-Jones DS, Ozanne SE, Koulman A. A high throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Analytical and Bioanalytical Chemistry 2020; 412:2851-2862.
Sovio U, Goulding N, McBride N, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. A maternal serum metabolite ratio predicts term fetal growth restriction. Nature Medicine 2020;26:348-353.
de Goffau MC, Lager SM, Sovio U, Gaccioli F, Cook E, Peacock SJ, Parkhill J, Charnock-Jones DS, Smith GCS. Article: Human placenta has no microbiome but can contain potential pathogens. Nature 2019;572:329-334.
Hughes AE, Sovio U, Gaccioli F, Cook E, Charnock-Jones DS, Lawlor DA, Smith GCS. The association between first trimester AFP to PAPP-A ratio and placentally-related adverse pregnancy outcome. Placenta 2019;81:25-31.
Sovio U, McBride M, Wood AM, Masconi KL, Cook E, Gaccioli F, Charnock-Jones DS, Lawlor DA, Smith GCS. 4-hydroxyglutamate is a novel predictor of preeclampsia. International Journal of Epidemiology 2020;49:301-311
Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gomez G, Constância M (2020) Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet 16(10):e1009069. doi: 10.1371/journal.pgen.1009069. PMID: 33057429
Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria
S Tukwasibwe, A Nakimuli, J Traherne, O Chazara, J Jayaraman, … Cellular & Molecular Immunology 17 (8), 799-806
Sharing Knowledge With Young and Established Students of Immunology by the Neapolitan Gulf at the Ruggero Ceppellini Advanced School
F Colucci. Frontiers in immunology 11
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy
O Huhn, MA Ivarsson, L Gardner, M Hollinshead, JC Stinchcombe, … Nature communications 11 (1), 1-14
2019
Wastlund D, Moraitis AA, , Thornton JG, Sanders J, White IR, Brockelhurst P, Smith GCS, Wilson ECF. The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision-analysis. BJOG 2019;126:1243-1250.
Wastlund D, Moraitis AA, Dacey A, Wilson ECF, Sovio U, Smith GCS. Screening for breech presentation using universal late pregnancy ultrasonography: A prospective cohort study and cost-effectiveness analysis. PLoS Medicine 2019 6(4):e1002778.
Sovio U, Smith GCS. Evaluation of a simple risk score to predict preterm preeclampsia using maternal characteristics: a prospective cohort study. BJOG 2019;126:963–970.
Consortium of Metabolomics Studies. Smith GCS (author 57 out of 74). The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology 2019;188:991-1012.
Jayasuriya N, Hughes AE, Sovio U, Cook E, Charnock-Jones DS, Smith GCS. A lower maternal cortisol to cortisone ratio precedes clinical diagnosis of preterm and term preeclampsia by many weeks. Journal of Clinical Endocrinology & Metabolism 2019;104:2355-2366.
NKG2A educates uterine NK cells to optimise pregnancy in humans and mice. N Shreeve, J Traherne, U Sovio, D Hawkes, O Huhn, J Jayaraman, …Available at SSRN 3477575
The immunological code of pregnancy. F Colucci. Science 365 (6456), 862-863
Placentation and antitumor immunity regulated by a scaffolding protein in NK cells. F Colucci. Sci. Immunol 4 1
Killer-cell immunoglobulin-like receptors on the cusp of modern immunogenetics (vol 152, pg 556, 2017). F Colucci, J Traherne. IMMUNOLOGY 156 (4), 422-422
Correction: High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia. O Huhn, O Chazara, MA Ivarsson, C Retière, TC Venkatesan, PJ Norman, …Journal of immunology (Baltimore, Md.: 1950) 202 (6), 1904
ROLE OF KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR AND HUMAN LEUKOCYTE ANTIGEN-C GENETIC VARIANTS IN TRANSMISSION AND SEVERITY OF MALARIA IN UGANDA. S Tukwasibwe, J Traherne, O Chazara, A Mpimbaza, J Jayaraman, … AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 101, 106-106
Microbes, immunity and cancer in Capri: Another successful course of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology founded by Serafino Zappacosta. F Colucci, E Carbone. Wiley-Blackwell
Effects of Uterine Cells-Conditioned Media on Expression of DNMT3B and DNMT3C in Mouse Embryos Cultured in a Microfluidic Device. V Mancini, J Lu, F Colucci, PJ McKeegan, JD Huntriss, HM Picton, …Reproductive Sciences 26 (Supplement 1), 377A-377A
On-chip mouse embryo culture: Evaluation of effects of uterine cells-conditioned media on embryo development and gene expression. V Mancini, J Lu, F Colucci, PJ McKeegan, JD Huntriss, HM Picton, … Fertility 2019 Abstract Book, 18-18
2018
The metabolic and developmental impact of a novel microfluidic device for mammalian embryo culture
P McKeegan, F Colucci, C Espinilla Aguilar, V Pensabene, H Picton
Fertility 2019 Abstract Book, 14-14
Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop
MK Misra, DG Augusto, GM Martin, N Nemat-Gorgani, J Sauter, …
Human immunology 79 (12), 825-833 11
Spontaneous pulmonary hypertension in genetic mouse models of natural killer cell deficiency
MT Rätsep, SD Moore, S Jafri, M Mitchell, HJM Brady, O Mandelboim, …
American Journal of Physiology-Lung Cellular and Molecular Physiology 315 (6 … 16
Single-cell analysis identifies thymic maturation delay in growth-restricted neonatal mice
WA Bacon, RS Hamilton, Z Yu, J Kieckbusch, D Hawkes, AM Krzak, …
Frontiers in immunology 9, 2523 9
High-resolution genetic and phenotypic analysis of KIR2DL1 alleles and their association with pre-eclampsia
O Huhn, O Chazara, MA Ivarsson, C Retière, TC Venkatesan, PJ Norman, …
The Journal of Immunology 201 (9), 2593-2601 20
Molecular definition of group 1 innate lymphoid cells in the mouse uterus
I Filipovic, L Chiossone, P Vacca, RS Hamilton, T Ingegnere, JM Doisne, …
Nature communications 9 (1), 1-13 42
COUP DE T-CELL: DEFECTIVE PLACENTATION IMPEDES NEONATAL IMMUNITY
W Bacon, J Kieckbusch, R Hamilton, D Hawkes, Z Yu, C Abell, F Colucci, …
PLACENTA 69, E20-E20
The use of a novel microfluidic culture device and predictive metabolic profiling as a means to improve murine embryo developmental competence in vitro
PJ McKeegan, F Colucci, HM Picton, V Pensabene
AETE Proceedings 2018, 127-127
Mouse embryo assay to evaluate polydimethylsiloxane (PDMS) embryo-toxicity*
F Colucci, P McKeegan, HM Picton, V Pensabene
2018 40th Annual International Conference of the IEEE Engineering in … 3
A comparative analysis of immune privilege in pregnancy and cancer in the context of checkpoint blockade immunotherapy
TR Flint, JO Jones, M Ferrer, F Colucci, T Janowitz
Seminars in oncology 45 (3), 170-175 13
Maternal group 2 innate lymphoid cells control fetal growth and protect from endotoxin-induced abortion in mice
E Balmas, BMJ Rana, RS Hamilton, N Shreeve, J Kieckbusch, I Aye, …
bioRxiv, 348755 5
2017
Mikaelsson MA, Constancia M, Dent CL, Wilkinson LS and Humby T (2013). Placental programming of anxiety in adulthood revealed by Igf2-null models. Nat Commun. 4:2311
Sandovici I, Hammerle CM, Ozanne SE, and Constancia M (2013). Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes. Cell Mol Life Sci. 70:1575-1595
Staff AC, Benton SJ, von Dadelszen P, Roberts JM, Taylor RN, Powers RW, Charnock-Jones DS, and Redman CWG (2013). Redefining preeclampsia using placenta-derived biomarkers. Hypertension. 61(5): 932-942
Sovio U, Jones R, DOs Santos Silva I & Koupil I (2013). Birth size and survival in breast cancer patients from the Uppsala Birth Cohort Study. Cancer Causes & Control 24:1643-1651
Sovio U, Skow A, Falconer C, Park MH, Viner RM & Kinra S (2013). Improving prediction algorithms for cardiometabolic risk in children and adolescents. J Obesity (Online): Article ID 684782
Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Tall R, Henning BJ et al for the Early Growth Genetics (EGG) Consortium (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics. 45(1):76-82