A study reporting high-quality placenta transcriptome based on the POPS study is published in Nature Communications. The placenta is understudied and is commonly omitted from large-scale “-omic” analyses such as the Genotype-Tissue Expression (GTEx) project. This study enables tissue-wide comparison of transcriptome analyses, as well as identification of dysregulated transcripts in placentally-related adverse pregnancy outcomes […]
Evgeniya (Zhenya) Shmeleva and Francesco Colucci sum up the knowns of natural killer cells and infections during pregnancy in their paper published today in the Mucosal Immunology journal – the official publication of the Society for Mucosal Immunology. Shmeleva EV, Colucci F. Maternal natural killer cells at the intersection between reproduction and mucosal immunity. Mucosal […]
A study led by Ulla Sovio and Gordon Smith at the Department of Obstetrics and Gynaecology, published in The American Journal of Obstetrics and Gynecology, identified new biomarkers predictive of early term spontaneous labour. The team performed a secondary analysis of the Pregnancy Outcome Prediction study. They found that slowing of fetal growth velocity detected […]
The uterus of mammalian species (including humans and model organisms such as mice) contains many immune cells that are critical for a successful pregnancy. In a new paper published in the journal Immunity, Norman Shreeve and colleagues from Francesco Colucci’s group at the Department of Obstetrics and Gynaecology, together with their collaborators, studied the role […]
Congratulations to Professors Gordon Smith and Steve Charnock-Jones on the publication of their paper in Nature. The study is the first high-resolution survey of the genomic architecture of the human placenta, revealing specific patterns of mutation that are commonly found in childhood cancers In the first study of the genomic architecture of the human placenta, […]
Congratulations to Dr Francesco Colucci and co-authors whose article entitled “Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy” has featured in the Editors’ Highlights. Selection was made as the paper was recognised as some of the “most exciting Immunology work” published in Nature Communications.
A new study published in PLoS Genetics by Miguel Constância’s group shows that a gene called Igf2, which produces a protein similar to insulin, and is active only on the chromosome inherited from the father, is key for the control of pancreas size and function. Within the pancreas, Igf2 is mostly active in a specific […]
A new study published in the Journal of Physiology by Susanne Lager and colleagues shows that lesions and accumulation of specific immune cells in the placental tissue are more common in fetal growth restriction and pre‐eclampsia than in uncomplicated pregnancies. Read the full paper now.
A study by Ulla Sovio, Gordon Smith and colleagues, published in Nature Medicine, has identified metabolites predictive of fetal growth restriction (FGR) at term. FGR means that the fetus fails to grow according to its growth potential. The condition is a major cause of stillbirth, neonatal morbidity and mortality and is also associated with developmental […]
A study by Susanne Lager (Obstetrics and Gynaecology) and Marcus de Goffau (Veterinary Medicine and Wellcome Sanger Institute), led by Steve Charnock-Jones and Gordon Smith (both Obstetrics and Gynaecology), showed, conversely to other studies, that the placenta does not have a microbiome. The placenta is the critical interface between the mother and the growing foetus, transporting […]