Dr Francesca Gaccioli is delighted to be hosting the Cambridge Reproduction SRI Early Researchers Seminar Series taking place Thursday 10 June 2021 at 1pm. Presentations: Phenotypic and functional diversity of human placental macrophages Jake Thomas (PDN) Gender conformity and quality of life in heterosexual couples with fertility problems attending ART Lidia Bueno Sánchez (ReproSoc) Characterization […]
An ancient immunoreceptor educates maternal natural killer cells to optimise reproduction
Francesco Colucci is presenting at the Cambridge Immunology and Medicine webinar series Friday 21 May 1-2pm. His talk is entitled “An ancient immunoreceptor educates maternal natural killer cells to optimise reproduction.” Visit Cambridge Reproduction to find out more.
Congratulations to Sung Gong, Professor Steve Charnock-Jones and colleagues on their ‘shiny’ new paper.
A study reporting high-quality placenta transcriptome based on the POPS study is published in Nature Communications. The placenta is understudied and is commonly omitted from large-scale “-omic” analyses such as the Genotype-Tissue Expression (GTEx) project. This study enables tissue-wide comparison of transcriptome analyses, as well as identification of dysregulated transcripts in placentally-related adverse pregnancy outcomes […]
Maternal natural killer cells at the intersection between reproduction and mucosal immunity
Evgeniya (Zhenya) Shmeleva and Francesco Colucci sum up the knowns of natural killer cells and infections during pregnancy in their paper published today in the Mucosal Immunology journal – the official publication of the Society for Mucosal Immunology. Shmeleva EV, Colucci F. Maternal natural killer cells at the intersection between reproduction and mucosal immunity. Mucosal […]
Slowing of fetal growth and elevated maternal serum sFLT1:PlGF are associated with early term spontaneous labor
A study led by Ulla Sovio and Gordon Smith at the Department of Obstetrics and Gynaecology, published in The American Journal of Obstetrics and Gynecology, identified new biomarkers predictive of early term spontaneous labour. The team performed a secondary analysis of the Pregnancy Outcome Prediction study. They found that slowing of fetal growth velocity detected […]
The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice
The uterus of mammalian species (including humans and model organisms such as mice) contains many immune cells that are critical for a successful pregnancy. In a new paper published in the journal Immunity, Norman Shreeve and colleagues from Francesco Colucci’s group at the Department of Obstetrics and Gynaecology, together with their collaborators, studied the role […]
HOD Professor Gordon Smith new Sands Ambassador
We are delighted to share that our Head of Department, Professor Gordon Smith has taken on the role of Ambassador for Sands (Stillbirth and neonatal death charity) to help drive the charity’s ground-breaking work to save babies’ lives. His internationally recognised research is looking for better ways to predict problems in pregnancy so babies and mothers […]
Early Researchers Seminar Series
Dr Irving Aye is delighted to be hosting the Cambridge Reproduction SRI Early Researchers Seminar Series taking place Thursday 8 April 2021 at 1pm. Presentations: High dimensional analysis of human placental macrophages and the identification of novel emerging populations during pregnancy Anna Appios (Pathology) Changes in placental mitochondrial function are associated with fetal weight variation […]
Placenta is a dumping ground for genetic defects
Congratulations to Professors Gordon Smith and Steve Charnock-Jones on the publication of their paper in Nature. The study is the first high-resolution survey of the genomic architecture of the human placenta, revealing specific patterns of mutation that are commonly found in childhood cancers In the first study of the genomic architecture of the human placenta, […]
Nature Communications – Editors Highlights
Congratulations to Dr Francesco Colucci and co-authors whose article entitled “Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy” has featured in the Editors’ Highlights. Selection was made as the paper was recognised as some of the “most exciting Immunology work” published in Nature Communications.