In this Perspective published in Science, Francesco Colucci outlines the complex interactions between maternal immune cells and fetal trophoblast and the impact on pregnancy complications. Colucci F (2019). The immunological code of pregnancy. Science 365(6456): 862-863
A study by Susanne Lager (Obstetrics and Gynaecology) and Marcus de Goffau (Veterinary Medicine and Wellcome Sanger Institute), led by Steve Charnock-Jones and Gordon Smith (both Obstetrics and Gynaecology), showed, conversely to other studies, that the placenta does not have a microbiome. The placenta is the critical interface between the mother and the growing foetus, transporting […]
The uterus of humans and mice is home to many immune cells, including natural killer (NK) and other innate lymphoid cells (ILCs), which may play important roles in pregnancy. The uterine mucosa dynamically adapts to both the menstrual cycle and pregnancy and therefore it is particularly hard to study. A paper in Nature Communications by […]
We would like to congratulate Cristine on being awarded her PhD. Her thesis is entitled “Monitoring of cerebral oxygenation, cerebrovascular reactivity and cardiac function in preterm infants”. Dr Topun Austin was her supervisor. Well done!
Congratulations to Research Associate Dr Wendi Bacon whose abstract has won her a YW Loke New Investigator Travel Award to attend the IFPA conference in Tokyo this coming September. Well done Wendi!
Congratulations to Dr Irving Aye who has been awarded a 3-year Next Generation Fellowship by the Centre for Trophoblast Research. Next Generation Fellowships are aimed at promoting the career prospects of high-calibre individuals pursuing innovative research falling within the remit of the Centre, with special reference to the trophoblast. Further information can be found here.
CTR PhD student Oisin Huhn has won the first prize for best poster at the 18th Cambridge Immunology Forum, a one-day conference attended by Editors of Nature and Science who judged the posters. Oisin Huhn is a PhD student in the Colucci Lab.
Metal growth restriction is a major determinant of an adverse perinatal outcome. Screening procedures for fetal growth restriction need to identify small babies and then differentiate between those that are healthy and those that are pathologically small. We sought to determine the diagnostic effectiveness of universal ultrasonic fetal biometry in the third trimester as a […]
One in 200 babies dies before birth in the UK. A study aimed at determining how to reduce the risk of a pregnancy coming to a devastating end is now producing its first results. Read the full article here: http://www.cam.ac.uk/research/features/getting-the-true-measure-of-pregnancy
Abstract NK cells express variable receptors that engage polymorphic MHC class I molecules and regulate their function. Maternal NK cells accumulate at the maternal-fetal interface and can interact with MHC class I molecules from both parents. The relative contribution of the two sets of parental MHC molecules to uterine NK cell function is unknown. Here […]