Francesco Colucci

Current Position

University Reader in Immunology

Department of Obstetrics and Gynaecology

Telephone +44 (0)1223 763889

Email fc287@medschl.cam.ac.uk

 

Current Research Interests

  • Immune cells at the fetal-maternal interface
  • Control of tumor growth by immunity
  • Cell transplantation

 

Brief CV

  • University Reader, University of Cambridge Clinical School, Cambridge, UK (since October 2011)
  • Fellow, King’s College, Cambridge, UK (since 2010)
  • Senior Lecturer, University of Cambridge Clinical School, Cambridge, UK (since 2010)
  • Co-founder of Dando, Weiss & Colucci Limited (since 2005), a management company that facilitates biomedical research
  • Group Leader (2004-2010), Babraham Institute, Cambridge, UK
  • Chargé de Recherche (2000-2004), Pasteur Institute, Paris
  • Post-doctoral training (1997-2000), Necker University Hospital, Paris, France
  • PhD (1997) in Cell and Molecular Biology, University of Umeå, Sweden
  • MD and Medical Board Certificate (1991), University of Bari, Italy

 

Key Publications

Ali TH, Pisanti S, Ciaglia E, Mortarini R, Anichini A, Garofalo C, Tallerico R, Santinami M, Gulletta E, letto C, Galgani M, Matarese G, Bifulco M, Ferrone S, Colucci F, Moretta A, Kärre K, and Carbone E (2014). Enrichment of CD56(dim)KIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients. Nat. Comms. 5: 5639 DOI 10.1038/ncomms6639

Colucci F, Moffett A, and Trowsdale J (2014). Medawar and the immunological paradox of pregnancy: 60 years on. Eur J. Immunol. 44(7): 1883-1885

Kieckbusch J, Gaynor LM, Moffett A and Colucci F (2014). MHC-dependent inhibition of uterine NK cells impeded fetal growth and decidual vascular remodelling. Nat. Comms. 5: 3359 DOI 10.1038/ncomms4359

Moffett A, and Colucci F (2014). Uterine Natural Killer cells: Active regulators at the Maternal-fetal interface. J. Clin Invest. 124(5): 1872-1879

Colucci F, Boulenouar S, Kieckbusch K, and Moffett A (2011). How does variability of immune system genes affect placentation? Placenta. 32(8): 539-545. Epub 2011 Jun 12

Doisne JM, Tan TC, and Colucci F (2011). Guardian of the genome turns on genes that alert natural killer cells. Cell Cycle. 10(22): 3822-3823

Madeja M, Yadi H, Richard Apps R, Boulenouar S, Roper S, Gardner L, Moffett M, Colucci F, and Hemberger M (2011). Paternal MHC expression on mouse trophoblast affecte uterine vascularization and fetal growth. PNAS 108(10): 4012-4017. Epub 2011 Feb 7

Li P, Burke S, Wang J, Chen X, Ortiz M, Lee S, Lu D, Campos L, Goulding D, Ling Ng B, Dougan G, Huntly B, Gottgens B, Jenkins NA, Copeland NG, Colucci F, and Liu P (2010). Reprogramming of T cells to Natural Killer-like upon Bcl11b deletion. Science. DOI:10.1126/science.1188063

Colucci F, and Cilio CM (2010). Taming killer cells may halt diabetes progression. Nat Immunol. 11: 111-112

Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Hoglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Karre K, Shibuya A, Carbone E, and Colucci F (2009). NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J. Clin. Invest. 119: 1251-1263

Saudemont A, Garcon F, Yadi H, Roche-Molina M, Segonds-Pichon A, Martin-Fontecha A, Okkenhaug K, and Colucci F (2009). The p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health disease. PNAS. 106: 5795-5800

Yadi H, Burke S, Madeja Z, Moffett A, and Colucci F (2008). Unique receptor repertoire in mouse uterine NK cells. J. Immunol. 181: 6140-6147

Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, and Colucci F (2007). The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. Blood. 110: 3202-3208

Caraux A, Kim N, Bell SE, Zompi S, Ranson T, Lesjean-Pottier S, Garcia-Ojeda ME, Turner M, and Colucci F (2006). Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood. 107: 994-1002

Colucci F, Caligiuri MA, and Di Santo JP (2003). What does it take to make a natural killer? Nat Rev Immunol. 3: 413-425

Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, and Colucci F (2003). NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol. 4: 565-572

Colucci F, Di Santo JP, and Leibson PJ (2002). Natural killer cell activation in mice and men: different triggers for similar weapons? Nat Immunol. 3: 807-813

Colucci F, Schweighoffer E, Tomasello E, Turner M, Ortaldo JR, Vivier E, Tybulewicz VL, and Di Santo JP (2002). Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nat Immunol. 3: 288-294

Colucci F, Bergman ML, Penha-Goncalves C, Cilio CM, and Holmberg D (1997). Apoptosis resistance of non-obese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. PNAS. 94: 8670-8674