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Miguel Constância

Dr Miguel Constância
Tel: +44 (0)1223 336873
E-mail: jmasmc2@cam.ac.uk

Brief CV

  • BSc in Biology (1988), MSc Cancer Biology (1993), University of Porto, Portugal
  • PhD (2000), University of Cambridge, UK
  • Career Progression Fellow (2003-2004) and BBSRC David Phillips Fellow (2004-2007), The Babraham Institute, Cambridge, UK
  • NET member of Epigenetics EU Network of Excellence (since June 2006)
  • Lecturer in Reproductive Biology, University of Cambridge, UK (since October 2007)
  • Investigator of the Institute of Metabolic Sciences, University of Cambridge, UK (since October 2007)

Current Research Interests

  • Imprinting, placental function and fetal growth
  • Epigenetic basis of metabolic disease
For further information see IMS Metabolic Research Laboratories.

Key Publications


Ozanne S & Constância M
Mechanisms of Disease: The developmental origins of disease and the role of the epigenotype.
Nat Clin Pract Endo & Met (2007) 3: 539-546.

Constância M, Angiolini E, Sandovici I, Smith P, Smith R, Kelsey G, Dean W, Ferguson-Smith A, Sibley CP, Reik W & Fowden A.
Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
Proc Natl Acad Sci USA (2005) 102: 19219-24.

Sibley CP, Coan PM, Ferguson-Smith AC, Dean W, Hughes J, Smith P, Reik W, Burton GJ, Fowden AL & Constância M
Placental-specific Insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.
Proc Natl Acad Sci USA (2004) 101:8202-8.

Constância M, Kelsey G & Reik W
Resourceful Imprinting.
Nature (2004) 432: 53-7.

Constância M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C & Reik W
Placental Igf2 is a major modulator of fetal growth.
Nature (2002) 417: 945-948.

Constância M, Dean W, Lopes S, Moore T, Kelsey G & Reik W
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.
Nature Genet (2000) 26: 203-206.

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